Phenoloxidase Activity Acts as a Mosquito Innate Immune Response against Infection with Semliki Forest Virus
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Phenoloxidase Activity Acts as a Mosquito Innate Immune Response against Infection with Semliki Forest Virus
Several components of the mosquito immune system including the RNA interference (RNAi), JAK/STAT, Toll and IMD pathways have previously been implicated in controlling arbovirus infections. In contrast, the role of the phenoloxidase (PO) cascade in mosquito antiviral immunity is unknown. Here we show that conditioned medium from the Aedes albopictus-derived U4.4 cell line contains a functional P...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2012
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1002977